Reality star: Jamie Sangouthai, shown earlier this year in an Instagram snap, died on Sunday of a reported drug overdose
The gossip website reported that Sangouthai died on Sunday at a hospital in downtown Los Angeles after 911 was called.
Some linked and even blamed Sangouthai for Odom's alleged crack cocaine abuse two years ago during his split from his estranged wife.
However, he was remembered fondly by those who knew him, including Khloe's best friend Malika Haqq who posted a snap on Sunday of all of them to Instagram.
Estranged couple: Khloe Kardashian, shown with estranged husband Lamar Odom in June 2012, tweeted about Jamie's death
Broken heart: The reality star shared her broken heart on Twitter
She accompanied the photo with the note: 'Thru good and bad times life shows us every spirit matters and leaves a print on the hearts of others after they have passed... RIP Jamie Sangouthai #GodHelpUsAll'.
Sangouthai and Odom both grew up in the Queens borough of New York City and were longtime friends.
They were partners in a clothing line titled Rich Soil that Khloe questioned during the two-season run of Khloe & Lamar.
RIP: Malika Haqq shared a snap of herself with Khloe, Lamar and Jamie upon learning of his death
Sangouthai was diagnosed with the digestive disease diverticulitis in 2008 that required three surgeries.
He told the Los Angeles Times in April 2011 that Odom helped with his medical expenses and also had his Los Angeles Lakers teammates call him with well wishes.
Odom, 35, lost his mother to colon cancer when he was aged 12 and his father was a heroin addict.
Tough times: Lamar, shown in February in Los Angeles, faced another hardship with the death of his friend
His infant son Jayden with ex-girlfriend Liza Morales died from Sudden Infant Death Syndrome in June 2006 while sleeping in his crib in New York.
The former Lakers star was arrested in August 2013 on charges of driving under the influence and pleaded no contest in December 2013.
Khloe filed for divorce from Lamar in December 2013 but it has yet to be finalized.
Longtime friend: Jamie, shown in April 2011 in Beverly Hills, California, and Lamar both grew up in Queens
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